Young colorectal cancer is on the rise globally

- Advertisement -spot_imgspot_img

It is high time to gain more insight into the etiology of colorectal cancer in people younger than 50 years. This is the conclusion of Mario Giannakis and Kimmie Ng (Dana-Farber Cancer Institute and Harvard Medical School, Boston, USA) in Science. Since the 1990s, the age-adjusted incidence of this cancer has increased in many countries at what they call an ‘alarming rate’ of 2 to 4 percent per year, with an even greater increase in those under the age of 30. If the trend continues, it will become the leading cause of cancer death in the US in people aged 20 to 49 by 2030.

Other clinical presentation

How this happens is not well known. The clinical presentation is usually different from that of colon cancer in old age: the tumor is usually located on the left side of the colon and rectum. These patients are also often diagnosed when the disease is already in a more advanced stage. This is probably partly due to the fact that there are no screening programs for this age group, and partly because it may be a more aggressive form of the disease.

Genetic predisposition

It is certain that genetic predisposition plays an important role in younger people, such as Lynch syndrome. But that, according to Giannakis and Ng, cannot explain the observed increase. It is now clear that well-known risk factors such as obesity, a sedentary lifestyle, hypertension, hyperlipidaemia, hyperglycaemia and diabetes mellitus type 2 and a consumption pattern with a lot of sugary soft drinks, red and processed meat, but also the increasing use of antibiotics play a significant role. .

- Advertisement -spot_imgspot_img
Latest news
- Advertisement -spot_img
Related news
- Advertisement -spot_img